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56 Discoveries and innovations disclosed with potential for development of products for public benefit (15 invention pre-disclosures, 12 invention disclosures);

62 Agreements executed executed to facilitate the transfer of materials to research & partners (MTA's);

49 Agreements executed to facilitate the exchange confidential information to research & commercialization partners(CDA's & NDA's);   

5 License agreements executed with research and commercialization partners;   

8 US Patents issued; 

13 US Patent Applications filed;

$144,997 License income generated by ECU inventions and innovations

6 ECU start-up companies established from ECU inventions (3 Located in North Carolina and 2 located in Greenville);

19 Number of people employed by ECU start-up companies;

14 Small business with licenses for development of products based on ECU inventions and innovations;

East Carolina University - Issued U.S. Patents 

U.S. Patent No. 8,287,462 Systems, methods and products for diagnostic hearing assessments distributed via the use of a computer networkInventor(s): Gregg D.Givens, David C. Balch, Timothy Murphy, Adrian Blanarovich, and Patrick KellerIssued: October 16, 2012Abstract: The systems, methods and associated devices performing diagnostic hearing tests which use a computer network to allow interaction between a test administration site and one or a plurality of remote patient sites. The test can be administeredby an audiologist or clinician at a site remote from the patient, in a manner, which can allow interaction between the user and the clinician during at least a portion of the administration of the test. The diagnostic hearing tests canbe performed such that they meet standardized guidelines such as ANSI requirements or certification standards and can include distortion product emission level measurements or middle ear compliance measurements.

U.S. Patent No. 8,257,243 Frequency altered feedback for treating non-stuttering pathologiesInventor(s): Michael P. Rastatter, Joseph S. Kalinowski, and Andrew M. StuartIssued: September 4, 2012Abstract: Methods and devices treat treating non-stuttering pathologies having impaired or decreased communication skills by administering a frequency altered auditory feedback signal to a subject having a non-stuttering pathology while the subject is speaking or talking to thereby improve the subject's communication skills.

U.S. Patent No. 7,358,039 Fixed-dried red blood cellsInventor(s): Thomas Fischer, Marjorie Read, Arthur Bode, Timothy NicholsIssued: April 15, 2008Abstract: Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by means of cross-linkers with aldehyde functions such as paraformaldehyde or glutaraldehyde either alone or in combination. Native oxygen kinetics are achieved by preparing the red blood cells with 1,6-diphosphofructose. Blood group antigens and chemical functions that render the lyophilized RBCs thrombogenic are occluded by chemically attaching polyoxyethylene glycol polymers to the surface membrane of the red blood cells. The cross-linked red blood cells are preferably died by lyophilization.

U.S. Patent No. 7,349,523 Radiation isocenter measurement devices and methods and 3-D radiation isocenter visualization systems and related methodsInventor(s): Todd Jenkins, Ron Allison, Claudio SibataIssued: March 25, 2008Abstract: A three-dimensional phantom assembly for use with a radiation treatment device includes a three-dimensional support member having at least two, spaced apart opposed surfaces configured to hold at least one generally planar radiation sensitive dosimeter sheet such that the dosimeter sheet generally conforms to a shape defined by the two opposed surfaces. During irradiation, a radiation beam trajectory passes through the two opposed surfaces. Related systems methods for determining a radiation isocenter and/or generating a 3-D visualization of the radiation isocenter using radiation patterns obtained using a phantom are also described.

U.S. Patent No. 7,083,648 Tissue lockable connecting structuresInventor(s): Chang Yu, Glenn HarrisIssued: August 1, 2006Abstract: Percutaneous skin access devices include a plurality of locked connecting units mounted to the exterior surface of an implantable medical object which, in position, is configured to penetrate the skin of a subject. The locked connecting units may be mounted directly onto the desired surface of the exterior of the device or may be held on a substrate sheet, which is mounted to the exterior surface of the device. In position, the locked connecting units engage with soft tissue which can include the skin to form a bio-junction layer which includes mechanical and bio-sealing connection between the device body and the soft tissue. The configuration at the bio-junction layer secures the medical object in location in the subject even for long-term indwelling applications in a manner, which inhibits soft tissue infection.The locked connecting units may be rigid or semi-rigid for longer-term indwelling applications, and semi-rigid and/or resilient for shorter term indwelling applications. The locked connecting units may take on the form of rings, hooks, or loops having aperture or gap width/length sizes of from about 0.2 4 mm. The rings, loops, or hooks may connect with any soft tissue including skin as well subcutaneous tissue. The rings, hooks, or loops may be released from the skin/tissue without requiring surgical cutting procedures.The locked connecting units may be configured as a semi-rigid mesh collar arranged about the primary body providing access to the subject such that it resides in the subject and engages with the skin (epidermal/dermal layer). The mesh collar can be described as a particular type of ring or loop structure as the mesh defines the gap provided in individual loop configurations. The mesh collar may be used alone, or in combination with the loops, rings, or hooks. A skin stop collar having increased rigidity may be disposed under the mesh collar.

U.S. Patent No. 7,078,528 Biimidazole diamide anion binding agentsInventor(s): William Allen, Corey CauseyIssued: July 18, 2006Abstract: Biimidazole diamide compounds that are useful for binding anions such as sulfate are described, along with the use thereof for purposes such as extracting anions from a waste stream and/or detecting anions.

U.S. Patent No. 7,034,007 Low adenosine anti-sense oligonucleotide, compositions, kit & method for treatment of airway disorders associated with bronchoconstriction, lung inflammation, allergy(ies) & surfactant depletionInventor(s): Jonathan Nyce, James MetzgerIssued: April 25, 2006Abstract: An in vivo method of selectively delivering a nucleic acid to a target gene or mRNA, comprises the topical administration, e.g. to the respiratory system, of a subject of a therapeutic amount of an oligonucleotide (oligo) that is anti-sense to a mRNA complementary to the gene in an amount effective to reach the target polynucleotide and reducing or inhibiting expression. The composition and formulations are used for prophylactic, preventive and therapeutic treatment of ailments associated with impaired respiration, lung allergy(ies) and/or inflammation and depletion lung surfactant or surfactant hypoproduction, such as pulmonary vasoconstriction, inflammation, allergies, allergic rhinitis, asthma, impeded respiration, lung pain, cystic fibrosis, bronchoconstriction. The treatment of this invention may be administered directly into the respiratory system of a subject so that the agent has direct access to the lungs, in an amount effective to reduce or inhibit the symptoms of the ailment.

U.S. Patent No. 7,031,922 Methods and devices for enhancing fluency in persons who stutter employing visual speech gesturesInventor(s): Joseph Kalinowski, Andrew Stuart, Michael RastatterIssued: April 18, 2006Abstract: Methods, devices, and computer program products display visual choral speech to a patient who stutters or has a speech impediment or impairment as a visual stimulus for the patient to enhance the fluency of the patient. The visual choral speech is incongruous with the speech produced by the stutterer and is provided by a visual display of the articulatory movements of a person other than the patient (or a simulated representation thereof) of the person's lips and mouth as the person speaks. The visual speech gestures can be displayed to the patient in advance of a speaking event or speech production by the stutterer and/or concurrently with a speaking event (either intermittently or continuous during the speaking event). The visual choral speech gestures can be based on a string of coherent words to provide the visual speech gestures signal such that it is relayed to the user without the attendant auditory component allowing the user to speak at a substantially normal pace with enhanced fluency.

U.S. Patent No. 6,916,291 Systems, methods and products for diagnostic hearing assessments distributed via the use of a computer networkInventor(s): Gregg Givens, David Balch, Timothy Murphy, Adrian Blanarovich, Patrick KellerIssued: July 12, 2005Abstract: The systems, methods and associated devices performing diagnostic hearing tests which use a computer network to allow interaction between a test administration site and one or a plurality of remote patient sites. The test can be administered by an audiologist or clinician at a site remote from the patient, in a manner, which can allow interaction between the user and the clinician during at least a portion of the administration of the test. The diagnostic hearing tests can be performed such that they meet standardized guidelines such as ANSI requirements or certification standards and can include distortion product emission level measurements or middle ear compliance measurements.

U.S. Patent No. 6,897,950 Laser tweezers and Raman spectroscopy systems and methods for the study of microscopic particlesInventor(s): Yong-Qing Li, Mumtaz DinnoIssued: May 24, 2005Abstract: Methods and systems for studying microscopic particles are provided. An optical trap for a selected microscopic particle can be formed with a laser beam at a first power level. The laser beam can have a variable power level associated therewith. The variable power level can be increased to a second power level. The laser beam at the second power level can produce Raman scattering signals. The second power level can provide sufficient excitation energy to the selected microscopic particle to produce Raman scattering signals and the second power level is higher than the first power level. A Raman spectrum can be detected from the Raman scattering signals produced by the laser beam at the second power level.

U.S. Patent No. 6,884,573 Fixed dried red blood cells and method of useInventor(s): Thomas Fischer, Marjorie Read, Arthur Bode, Timothy NicholsIssued: April 26, 2005Abstract: Fixed-dried red blood cells (RBCs), and processes for preparing the same are disclosed. The red blood cells, upon reconstitution with distilled water or appropriate buffer: bind oxygen with native affinities, have partial deformability, present minimal thrombogenicity to platelets, and have oblated blood group antigens. The RBCs are preferably fixed by means of cross-linkers with aldehyde functions such as paraformaldehyde or glutaraldehyde either alone or in combination. Native oxygen kinetics are achieved by preparing the red blood cells with 1,6-diphosphofructose. Blood group antigens and chemical functions that render the lyophilized RBCs thrombogenic are occluded by chemically attaching polyoxyethylene glycol polymers to the surface membrane of the red blood cells. The cross-linked red blood cells are preferably died by lyophilization.

U.S. Patent No. 6,825,174 Composition, formulations & method for prevention & treatment of diseases and conditions associated with broncho constriction, allergy(ies) & inflammationInventor(s): Jonathan W. NyceIssued: November 30, 2004Abstract: A pharmaceutical composition effective for preventing and alleviating bronchoconstriction, lung allergy(ies) and inflammation comprises a surfactant and an oligonucleotide anti-sense to an adenosine receptor gene, flanking regions or regions bridging the intro/exon borders, analogues which bind thymidine but have low adenosine content or exhibit lower or no adenosine receptor agonist activity, or antisense to the corresponding mRNA, combinations, sales or mixtures thereof, and a carrier, and optionally other therapeutic agents and formulation products. The composition is formulated for administration by a multiplicity of routes, and finds applications in the prevention and treatment of asthma, kidney damage or failure, ARDS, pulmonary vasoconstriction, inflammation, allergies, impeded respiration, respiratory distress syndrome, pain, cystic fibrosis, pulmonary hypertension, pulmonary vasoconstriction, emphysema, chronic obstructive pulmonary disease (COPD), and cancer, to counter the renal damage and failure associated with ischemic conditions and the administration of certain drugs and radio active diagnostic and therapeutic agents, as well as a joint therapy with the administration of adenosine and adenosine-like agents in the treatment of arrhythmias such as SVT and in cardiovascular function tests (stress tests). The present agent(s) is (are) also suitable for administration before, during and after other treatments, including radiation, chemotherapy, antibody therapy, phototherapy and cancer, and other types of surgery.

U.S. Patent No. 6,824,979 Catabolite repression control (Crc) gene and Pseudomonas virulenceInventor(s): Paul V. Phibbs, David N. Collier, Paul W. HagerIssued: November 30, 2004Abstract: The present invention relates to a method of screening for compounds that inhibit the virulence of Pseudomonas bacteria and comprises the steps of: providing a culture medium comprising Pseudomonas bacteria, administering a test compound to said bacteria, and then detecting the presence or absence of inhibition of the catabolite repression control (Crc) protein in the bacteria. The inhibition of the Crc protein indicates that the compound has antivirulence activity against Pseudomonas bacteria. Antisense oligonucleotides that inhibit expression of the Crc protein in a Pseudomonas bacteria and is nuclease resistant are also disclosed. Antivirulence compounds and the uses thereof in treating Pseudomonas infections are also disclosed.

U.S. Patent No. 6,754,632 Methods and devices for delivering exogenously generated speech signals to enhance fluency in persons who stutterInventor(s): Joseph Kalinowski, Andrew Stuart, Michael RastatterIssued: June 22, 2004Abstract: Methods and devices generate an exogenous natural second speech signal as an auditory stimulus to a user to enhance the fluency of persons who stutter. The natural speech signal is independent of the contemporaneous speech production of the stutterer and is provided by a voice gesture and can be a prolonged or sustained voice gesture sound such as a simple vowel, or consonant, or vowel trains and the like. The second speech signal can be transmitted in advance of a speaking event or speech production of the stutterer and/or concurrently with a speaking event, either intermittently or continuous during the speaking event. The devices of the instant invention are configured to provide the voice based speech signal such that it is audible to the user and does not require feedback of the user's own speech allowing the user to speak at a substantially normal pace with enhanced fluency. The device and methods can relay the signal based on a manual activation or automatically based on a detection of speech or a stuttering event on the part of the user.

U.S. Patent No. 6,670,349 Composition & Method for altering levels of or sensitivity to adenosine with a dehydroepiandrosterone and /or a ubiquinoneInventor(s): Jonathan W. NyceIssued: December 30, 2003Abstract: A method of treating adenosine depletion in a subject in need of such treatment is disclosed. The method comprises administering to the subject folinic acid or a pharmaceutically acceptable salt thereof in an amount effective to treat adenosine depletion. A method of treating asthma in a subject in need of such treatment is also disclosed. The method comprises administering to the subject dehydroepiandrosterone, analogs thereof, or pharmaceutically acceptable salts thereof in an amount effective to treat asthma.

 U.S. Patent No. 6,620,121 Pulse wave generator for cardiopulmonary bypass and extracorporealoxygenation apparatusInventor(s): Craig J. McCotterIssued: September 16, 2003Abstract: The present invention is a cardiopulmonary bypass and extracorporeal oxygenation apparatus that provides a pulsatile blood flow output. The apparatus comprises: a primary pump, which primary pump is preferably a continuous pump; an oxygenator in fluid communication with the primary pump; a pulse wave generator in fluid communication with the oxygenator and positioned downstream from the primary pump. The pulse wave generator comprises: (i) a collapsible chamber having an inlet opening and an outlet opening formed therein; (ii) a first one-way valve connected to the inlet opening and positioned to permit the flow of blood from the primary pump through the collapsible chamber. A compression assembly is operatively associated with the collapsible chamber and configured to alternately compress said collapsible chamber and permit the expansion of the collapsible chamber.

U.S. Patent No. 6,596,503 Monoclonal antibody DS6, tumor-associated antigen CA6, and methods of use thereofInventor(s): Anne Elizabeth Wennerberg, Diane A. SemerIssued: July 22, 2003Abstract: The present application describes a monoclonal antibody selected from the group consisting of monoclonal antibody DS6, monoclonal antibodies that specifically bind to the antigen or epitope bound by monoclonal antibody DS6, and fragments of the foregoing that specifically bind to the antigen or epitope bound by monoclonal antibody DS6. Methods of use of such antibodies and the isolated antigen bound by such antibodies are also described.

U.S. Patent No. 6,441,164 Wurster's crown ligandsInventor(s): John W. SibertIssued: August 27, 2002Abstract: Wurster's crown ligands comprise a macrocyclic ligand such as a crown ether in which a hetero atom is substituted with a 1,4-phenylenediamine group. The phenylenediamine group is covalently bound to the macrocyclic ligand by one or both of the amine nitrogens, the amine nitrogen thereby substituting for the hetero atom of the macrocyclic ligand. The resulting compounds are redox active. Methods of making and using the compounds are also disclosed.

U.S. Patent No. 6,432,924 Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminaseInventor(s): Jonathan W. NyceIssued: August 13, 2002Abstract: A composition, device, kit and method for countering or diagnosing cytidine deaminase or deoxycytidine deaminase over-expression or a disorder associated with it, or an increase in number or toxicity of pro-inflammatory cells that over-express cytidine deaminase or deoxycytidine deaminase or a disorder associated with it, utilizing an agent of the formula C.sub.7 N.sub.3 H.sub.8 O.sub.2 R.sup.1 R.sup.2 XX.sup.1, wherein X and X.sup.1 are each independently C or N, R.sup.1 is lower alkyl, alkenyl and alkynyl, halogen or haloalkyl, and R.sup.2 is H, --N.sub.3 --OH, amino or halogen; or pharmaceutically acceptable salts thereof.

U.S. Patent No. 6,426,330 Satiety inducing composition comprising Neuropeptide Y analogues and methods of inducing satiety and treating a disease or condition associated with itInventor(s): Jonathan W. Nyce, Sherry Ann LeonardIssued: July 30, 2002Abstract: Satiety inducing composition comprises Neuropeptide Y analogues which are effective for inducing satiety and for treating diseases and conditions associated with a lacking of, or having lowered, satiety.

U.S. Patent No. 6,262,258 Wurster's crown ligandsInventor(s): John W. SibertIssued: July 17, 2001Abstract: Wurster's crown ligands comprise a macrocyclic ligand such as a crown ether in which a hetero atom is substituted with a 1,4-phenylenediamine group. The phenylenediamine group is covalently bound to the macrocyclic ligand by one or both of the amine nitrogens, the amine nitrogen thereby substituting for the hetero atom of the macrocyclic ligand. The resulting compounds are redox active. Methods of making and using the compounds are also disclosed.

U.S. Patent No. 6,136,791 Agent and method for treating disorders associated with cytidine deaminase or deoxycytidine deaminase overexpressionInventor(s): JonathanW. NyceIssued: October 24, 2000Abstract: An agent of the chemical formula C.sub.7 N.sub.3 H.sub.8 O.sub.2 R.sup.1 R.sup.2 XX.sup.1, wherein X and X.sup.1 are each independently C or N but not simultaneously, R.sup.1 is lower alkyl, alkenyl or alkynyl, halogen or haloalkyl, and R.sup.2 is H, --N.sub.3 --OH, amino or halogen; or pharmaceutically acceptable salts thereof. A method of treating a disorder associated with the overexpression of cytidine deaminase or deoxycytidine deaminase comprises administering to a subject in need of the treatment a compound of the chemical formula ##STR1## wherein X and X.sub.1 are each independently C or N; R.sup.1 is lower alkyl, lower alkenyl, lower alkynyl, halogen, or haloalkyl; and R.sup.2 H, --N.sub.3, --OH, amino, or halogen; or a pharmaceutically acceptable salt thereof in an amount effective to treat the disorder. Pharmaceutical formulations useful in the method of the present invention are also disclosed. 

U.S. Patent No. 6,087,351 Method for reducing adenosine levels with a dehydroepiandrosterone and optionally a ubiquinoneInventor(s): Jonathan W. NyceIssued: July 11, 2000Abstract: A method and composition for reducing adenosine levels comprises administering a dehydroepiandrosterone, and optionally a ubiquinone. 

U.S. Patent No. 6,075,009 Neuropeptide Y analogues, compositions and methods of lowering blood pressureInventor(s): Jonathan Nyce; Sherry Ann LeonardIssued: June 13, 2000Abstract: Neuropeptide Y analogues, and their compositions are effective for lower blood pressure. 

U.S Patent No. 6,040,296 Specific antisense oligonucleotide composition & method for treatment of disorders associated with bronchoconstriction and lung inflammationInventor(s): Jonathan W. NyceIssued: March 21, 2000Abstract: A DNA comprises an oligonucleotide antisense to mRNA encoding an adenosine A.sub.1 or A.sub.3 receptor. The oligo is provided as a composition, various formulations, a capsule, and cartridge and in the form of a kit. The oligonucleotide of the invention is effective for reducing bronchoconstriction and/or allergy, and may be administered to a subject to treat respiratory ailments such as asthma and other conditions associated with the expression of adenosine receptors.

U.S. Patent No. 6,025,339 Composition, kit and method for treatment of disorders associated withbronchoconstriction and lung inflammationInventor(s): Jonathan W. NyceIssued: February 15, 2000Abstract: A method of reducing bronchoconstriction in a subject in need of suchtreatment is disclosed. The method comprises administering to the subject an Antisenseoligonucleotide molecule directed against the A.sub.1 or A.sub.3 adenosine receptor in anamount effective to reduce bronchoconstriction. The method is useful for treating patientsafflicted with asthma. Pharmaceutical formulations are also disclosed. 

U.S. Patent No. 5,994,315 Low adenosine agent, composition, kit and method for treatment of airway diseaseInventor(s): Jonathan Nyce; James W. MetzgerIssued: November 30, 1999Abstract: An oligonucleotide which is antisense to a mRNA encoding a polypeptide involved in airway disease(s) contains up to three adenosines per every 21 nucleotide a method of treating airway disease in a subject in need of such treatment comprises topically administering to the subject an antisense oligonucleotide in an amount effective to treat the airway disease, where the antisense oligonucleotide is essentially free of adenosine. Pharmaceutical formulations are also disclosed. 

U.S. Patent No. 5,993,804 Pharmaceutically acceptable fixed-dried human blood plateletsInventor(s): Marjorie S. Read; Robert L. Reddick; Arthur P. BodeIssued: November 30, 1999Abstract: Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution; adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.

U.S. Patent No. 5,961,443 Therapeutic device to ameliorate stutteringInventor(s): Michael Pierre Rastatter ; Joseph Stanley Kalinowski ; Andrew Michael StuartIssued: October 5, 1999Abstract: A device and method for ameliorating stuttering by providing an altered auditory feedback by employing a compact device configured for positioning in or adjacent the ear canal of an individual. The portable, self-contained device can be used on a "chronic" basis and includes a receiver for receiving auditory signals, an auditory delay and or frequency shift circuit, and a transmitter for transmitting the altered signal to the individual user.

U.S. Patent No. 5,922,674 Method of treatment using chemotherapy and erythropoietinInventor(s): Athanasius A. Anagnostou; George SigounasIssued: July 13, 1999Abstract: The use of human erythropoietin (EPO) to prevent or treat endothelial injury due to chemotherapy, radiation therapy, mechanical trauma, or to a disease state which damages the endothelium (such as inflammation, heart disease or cancer) is described. The use of EPO in conjunction with the administration of chemotherapeutic agents is described. 

U.S. Patent No. 5,902,608 Surgical aids containing pharmaceutically acceptable fixed-dried human blood plateletsInventor(s): Marjorie S. Read; Robert L. Reddick; Arthur P. BodeIssued: May 11, 1999Abstract: Fixed-dried human blood platelets and processes for preparing them are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Surgical aids containing such platelets are also disclosed. The platelets are preferably fixed by a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by a permanganate fixate. The platelets are preferably dried by lyophilization. 

U.S. Patent No. 5,891,393 Method for the microbial decontamination of blood plateletsInventor(s): Marjorie S. Read; Arthur P. Bode; Louis J. SummariaIssued: April 6, 1999Abstract: A method for inactivating microbiological contaminants in a human blood platelet preparation is disclosed. The method comprises, first, providing blood platelets, particularly human blood platelets, suspected of being contaminated with microorganisms. The platelets are then contacted to a fixative for a time sufficient to fix the platelets. After fixing, the platelets are preferably washed and dried to produce fixed-dried platelets. The step of contacting the platelets to a fixative is carried out for a time sufficient to kill some or all the of the contaminating microorganisms. 

U.S. Patent No. 5,665,706 Nerve growth induction, stimulation and maintenance and enzyme potentiationInventor(s): John Paul Da Vanzo; Joseph West Paul, Jr.Issued: September 9, 1997Abstract: A composition comprising nerve growth factor and 2-amino-1,1,3-tricyano-1-propene useful for the induction, stimulation, and maintenance of nerve growth, and methods of potentiating choline O-acetyltransferase and tyrosine hydroxylase by 2-amino-1,1,3-tricyano-1-propene are disclosed. 

U.S. Patent No. 5,660,835 Method of treating adenosine depletionInventor(s): Jonathan W. NyceIssued: August 26, 1997Abstract: A method of treating adenosine depletion in a subject in need of such treatment is disclosed. The method comprises administering to the subject folinic acid or a pharmaceutically acceptable salt thereof in an amount effective to treat adenosine depletion. A method of treating asthma in a subject in need of such treatment is also disclosed. The method comprises administering to the subject dehydroepiandrosterone, analogs thereof, or pharmaceutically acceptable salts thereof in an amount effective to treat asthma.

U.S. Patent No. 5,651,966 Pharmaceutically acceptable fixed-dried human blood plateletsInventors(s): Arthur P. Bode, Marjorie S. Read, Robert L. Reddick Issued: July 29, 1997 Abstract: Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Pharmaceutical formulations containing the same are also disclosed. The platelets are preferably fixed by means of a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by means of a permanganate fixate. The platelets are preferably dried by lyophilization.

U.S. Patent No. 5,554,590 Method of treating asthmaInventor(s): Robert H. Fisher; W. James Metzger; Ruth A. HenriksenIssued: September 10, 1996Abstract: A method of treating asthma in a subject in need of such treatment comprises contacting Asthma Reversal Factor to the respiratory epithelium of the subject. The active agent is preferably contacted to the subject's respiratory epithelium by causing the subject to inhale respirable particles comprised of the active agent. 

U.S. Patent No. 5,527,789 Method of inhibiting carcinogenesis by treatment with dehydroepiandrosterone and analogs thereofInventor(s): Johathan W. NyceIssued: June 18, 1996Abstract: A method of combatting cancer in a subject comprising administering to said subject dehydroepiandrosterone (DHEA) or an analog thereof in an amount effective to combat cancer is disclosed in which heart failure induced by the DHEA or analog thereof is combatted by administering to the subject a ubiquinone, in an amount effective to combat heart failure induced by the DHEA or analog thereof. A prefered DHEA analog for carrying out the invention is 16 alpha-fluoroepiandrosterone, and a preferred ubiquinone for carrying out the invention is Coenzyme Q.sub.10. 

U.S.Patent No. 5,475,019 Method of treating anxiety-related disorders with 2-aminocycloaliphatic amide compoundsInventor(s): Thomas H. Privette; David M. TerrianIssued: December 12, 1995Abstract: A method for combatting anxiety in a subject in need of such treatment is provided. The method comprises administering to the subject a 2-aminocycloaliphatic amide kappa opioid agonist in an effective anxiety-combatting amount. 

U.S. Patent No. 5,290,550 Method of treating asthma using IL-8Inventor(s): Robert H. Fisher; James MetzgerIssued: March 1, 1994Abstract: A method of treating asthma in a subject in need of such treatment comprises contacting Interleukin-8 or an active fragment thereof to the respiratory epithelium of the subject. The active agent is preferably human endothelial IL-8, and is preferably contacted to the subject's respiratory epithelium by causing the subject to inhale respirable particles comprised of the active agent. 

U.S. Patent No. 5,194,426 Method for nerve growth inductionInventor(s): John P. Da Vanzo; Paul, Jr.; Joseph W. Paul Jr.Issued: March 16, 1993Abstract: A composition comprising nerve growth factor and 2-amino-1,1,3-tricyano-1-propene useful for the induction, stimulation, and maintenance of nerve growth, and methods of potentiating choline O-acetyltransferase and tyrosine hydroxylase by 2-amino-1,1,3-tricyano-1-propene are disclosed.

 

U.S. Patent No. 5,167,135 Safety lockout adapter and coupling member used thereforInventor(s): David L. GobeskiIssued: December 1, 1992Abstract: A safety lockout adapter is formed of two coupling members. Each coupling member is adapted to couple with another corresponding coupling member of substantially similar configuration for locking-out power disconnects or fluid line disconnects. When connecting the members to the power disconnect handle, a worker must use both hands. Each coupling member comprises a substantially rigid and planar member having opposing front and rear edges and opposing side edges defining front and rear portions. The front portion includes on one of the side edges an arcuate portion extending inwardly to form a substantially concave cut-out and a hook portion defined by the front edge and projecting toward the side from the front of the concave cut-out. Means positioned along the side edge opposite the arcuate cut-out holds together two coupling members when reversed and coupled in overlapping registry with each other. The rear portion of each coupling member has a plurality of holes therein which are positioned to align with the holes of the other coupling member when both members are coupled together to permit padlocks to be inserted through the aligned holes.

U.S. Patent No. 4,994,367 Extended shelf life platelet preparations and process for preparing the sameInventor(s): Arthur P. Bode; William A. L. Heaton; Stein Holme; David T. MillerIssued: February 19, 1991Abstract: A first aspect of the present invention is a blood platelet preparation comprising blood platelets, an adenylate cyclase stimulator, a phosphodiesterase inhibitor, a thrombin inhibitor, and a plasmin inhibitor. A second aspect of the present invention is a plasma-free platelet storage medium containing dextrose, sodium citrate, sodium bicarbonate, and a platelet activation inhibitor, with a preferred platelet activation inhibitor comprising an adenylate cyclase stimulator in combination with a phosphodiesterase inhibitor. A third aspect of the present invention is a process for producing a plasma-free platelet preparation comprising producing platelet-rich plasma (PRP) from whole blood, adding a platelet activation inhibitor thereto, centrifuging the PRP to deposit the platelets on the bottom of the centrifuge container, removing the platelet-free plasma supernatant therefrom and adding a plasma-free liquid platelet storage medium thereto. A preferred platelet activation inhibitor for the process comprises an adenylate cyclase stimulator in combination with a phosphodiesterase inhibitor. A preferred adenylate cyclase stimulator is Prostaglandin El, a preferred phosphodiesterase inhibitor is Theophylline, a preferred plasmin inhibitor is Aprotinin, and a preferred thrombin inhibitor is N-(2-naphthylsulfonylglycyl)-D,L-amidinophenylalaninpiperidide. 

U.S. Patent No. 4,935,000 Extracellular matrix induction method to produce pancreatic islet tissueInventor(s): Ronald W. DudekIssued: June 19, 1990Abstract: A method and composition of regenerating tissue. More specifically, a method for regenerating pancreatic islet tissue having the histological and insulin-containing properties of islets typically found in neonatal or adult animals is described. The regenerated islet tissue is produced by fetal mesenchyme acting upon an epithelium such that an inductive message causes the epithelium to differentiate into islet tissue.

U.S. Patent No. D493,000 (Design Patent)Post Treatment Protector DeviceInventor(s): Sheila Grady, Laura Staubes, Janice Lalikos Issued: July 13, 2004

U.S. Patent No. D483,491 (Design Patent)Post treatment protector deviceInventor(s): Sheila Grady, Laura Staubes, Janice Lalikos Issued: December 9, 2003

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