Lab News

This is where we'll announce the most recent events. If you've visited us before and want to know what's changed, take a look here first.

• 02/15/2007  FASEB made public release about our new manuscript published online ahead of print. "Getting on your nerves ... and repairing them".
• 09/25/2006 Our new manuscript "RNAi Pathway is Functional in Peripheral Nerve Axons" by A.K. Murashov, V.Chintalgattu, R.R. Islamov, T.E. Lever, E.S. Pak, P.L. Sierpinski, L.C. Katwa, and M.R. Van Scott has been accepted to publication in  The FASEB Journal. Congratulations to everybody !!!
• 07/18/2006 "Pre-differentiated Embryonic Stem Cells Prevent Chronic Pain Behaviors and Restore Sensory Function Following Spinal Cord Injury in Mice." was puiblished ahead of print in Molecular Medicine.
• 07/17/2006  Review "Protein synthesis in the axon" Islamov RR, Murashov AK, Chelyshev IuA, is published in Morfologiia (Russian). 2005;128(6):70-6.
• 03/28/2006 Wesley's paper "Pre-differentiated Embryonic Stem Cells Prevent Chronic Pain Behaviors and Restore Sensory Function Following Spinal Cord Injury in Mice." is in press in Molecular Medicine. Congratulations!!!
• 07/12/2005  Dr. Murashov gave an interview to the editor of the weekly newsletter RNAi News Doug Macron.  It was published 7/15/2005 | Volume: 3 | number 27.  To read go to http://www.rnainews.com/
• New paper has been accepted for publication in Biochemical and Biophysical Research Communications!   "Parallel development of cardiomyocytes and neurons in embryonic stem cell culture" 
  In Press, Uncorrected Proof, Available online 10 May 2005
  Alexander K. Murashov, Elena S. Pak and Laxmansa C. Katwa
  SummaryPlus | Full Text + Links | PDF (373 K)
• 03/08/2005  Teresa Lever won Vice Chancellor’s Award  for her poster presentation at the ECU Graduate Research Day.  Teresa presented poster on our discovery of RNAi in mammalian axons. Teresa did a terrific job! Congratulations!!!
• 11/12/2004   Dr. Margarita Glazova has joined our lab as a postdoctoral Research Associate.   She has strong background in such classical disciplines as morphology and histophysiology of brain, and in modern procedures including molecular biology and biochemistry techniques, and isolation and culture of neuronal stem cells.
• 09/29/2004  Our new manuscript Directed Differentiation of Embryonic Stem Cells into Dorsal Interneurons by Murashov, A. K., E.S. Pak, W. A. Hendricks, J.P. Owensby, P. L. Sierpinski, L.M. Tatko and P.L. Fletcher has been accepted for publication in The FASEB Journal.
• 09/02/2004  Wesley A. Hendricks has successfully completed and defended his MS thesis.  His work resulted in three publications in peer review journals, including Brain Research and FEBS Letters.  Congratulations!!!
• 08/27/2004   Our paper “Induction of VEGF and its Flt-1 Receptor after Sciatic Nerve Crush Injury”  Rustem R. Islamov, Vishnu Chintalgattu, Elena S. Pak, Laxmansa C. Katwa and Alexander K. Murashov has been published  in NeuroReport, 2004, 15(13):2117-2121.
• 06/18/2004  New research proposal  submitted to the North Carolina Biotechnology Center has been approved for funding!  In the current application we propose to test the specific hypothesis that (a) ES cells predifferentiated into cortical progenitors, may develop upon transplantation into functional neurons and restore brain circuitry
• 05/19/2004 New paper "17b- Estradiol Enhances Neuronal Differentiation of Mouse Embryonic Stem Cells" by Murashov,A.K., Pak, E.S., Hendricks,W.A., Tatko, L.M.  , is in press in FEBS Letters, Vol 569/1-3 pp 165-168.
• 03/26/2004  Wes and Paulina won awards for their presentations at the ECU Research Day.  Our lab work was presented by Wesley Hendricks and Paulina Sierpinski. Wes presented poster on using stem cells for treatment of spinal cord injuries. Paulina gave a talk on RNAi in axonal fibers. Wes and Paulina did a great job! Congratulations!
• 03/23/2004  Our manuscript “Estrogen Increases Retrograde Labeling of Motoneurons: Evidence of a Non-Genomic Mechanism.” Alexander K. Murashov, Rustem R. Islamov, Roger J. McMurray, Elena S. Pak, Douglas A. Weidner, has been accepted and is eligible for immediate online publication in Articles in Press in AJP- Cell Physiology.
• 01/09/2004  Our stem cell paper will be published in Journal of Neurotrauma, 2004, Volume 21, Number 2, 163-174.  See uncorrected proof!
• 11/12/03  Daniel won the first prize at the Society for Neurotrauma Meeting!!! He presented our collaborative work on using stem cells in treating brain injuries.  He beat out Yale, UCLA, U Penn, and Univ. of Virginia.
• 10/29/03  New collaborative paper "Transplantation of Neuronal and Glial Precursors Dramatically Improves Sensorimotor Function but not Cognitive Function in the Traumatically Injured Brain" by Michael R. Hoane, G. Daniel Becerra, J. Elizabeth Shank, Lisa Tatko, Elena S. Pak , Michael Smith & Alexander K. Murashov has been accepted for publication to Journal of Neurotrauma.
• 10/23/03  VII ECU Annual Neuroscience Symposium.  Our lab presented four posters (C. Heery et al., W. Hendricks et al., P. Owensby et al., L. Tatko et al.) and one oral presentation (R. Islamov). It was a complete success!
• Roger J. McMurray has successfully completed and defended his MS thesis.  His work resulted in three publications in peer review journals, including Brain Research and Molecular Brain Research.  Congratulations!!!
• 06/26/2003 MS seminar presentation by Roger J. McMurray Thursday, June 26, 2003 at 10 AM in the Howell Science Complex N109.  The presentation is entitled the Effect of Selective Estrogen Receptor Modulator LY117018 on Peripheral Nerve Regeneration.
• 06/05/2003 New paper "Differential expression of endothelin receptors in regenerating spinal motor neurons in mice" by  Rustem Islamov, Vishnu Chintalgattu, Roger McMurray, Elena Pak, Alexander Murashov and Laxmansa C Katwa has been provisionally accepted for publication in Mol. Brain Res.
• 05/08/2003  Roger's paper "Raloxifene Analog LY117018 Enhances the Regeneration of Sciatic Nerve in Ovariectomized Female Mice" in press.
• 03/15/2003  Second Rustem's paper "Effect of 17 -estradiol on gene expression in lumbar spinal cord following sciatic nerve crush injury in ovariectomized mice" has been published in Brain Research, 2003, Mar 14;966(1):65-75.
• 12/10/2002  Rustem's paper entitled "Effect of 17 -estradiol on gene expression in lumbar spinal cord following sciatic nerve crush injury in ovariectomized mice" has been accepted to publication in  Brain Research.
• 11/13/2002  Society for Neuroscience Annual Meeting, Orlando, FL .  Our lab presented three posters (R. Islamov et al., G. Li et al., M. Smith et al.).  Rustem's and Mike's posters got a lot of attention!
• 10/11/2002  Mike's paper entitled "Development of the Mouse Vestibular System in the Absence of Gravity Perception" has been accepted to publication in Developmental Brain Research.
• 07/09/2002  Rustem's paper entitled "17b-Estradiol stimulates regeneration of sciatic nerve in female mice" has been published in Brain Research!
• 02/01/2002  Our proposal for purchase of the state-of-the-art Luminex-100 system has been approved for funding by ONR!  The Luminex100 is a new array system based on laser technology which allows performing up to 100 bioassays on a single sample.  This high throughput multiplex system will maximize our productivity in identifying cytokines and kinases involved in neural signaling during hemorrhagic shock.
• 01/2002  Rustem's paper under revision.  Mike has submitted his paper to Developmental Brain Research.
• 11/2001  Manuscripts submissions!  Lilia and Rustem have submitted two new papers based on their research findings to the Journal of Neuroimminology and Brain Research!
• 10/24/01 Stem Cells Culture Room has been established!  The new project will focus on use of embryonic and adult stem cells to treat neurological disorders, caused by trauma, stroke and ischemia.
• 10/17/01  ECU Annual Neuroscience Symposium.  Our lab presented three posters (R. Islamov et al., G. Li et al., M. Smith et al.) and two oral presentations (R. Islamov and M. Smith). It was a complete success.
• 06/19/01 New manuscript has been published!  New full-length report entitled "Crosstalk between p38, Hsp25 and Akt in spinal motor neurons after sciatic nerve injury" has been published  in Molecular Brain Research, 2001, Vol 93/2, pp 199-208.  Authors: Alexander K Murashov*, Ihtsham Ul Haq, Charles Hill, Eunice Park, Michael Smith, Xiang Wang, Xiangyuang Wang, Daniel J Goldberg, Debra J Wolgemuth
• 09/28/00  New research proposal  submitted to the Department of the Navy has been approved for funding!
  The proposal is focused on mechanism by which peripheral pro-inflammatory cytokines activate central neuroendocrine response in the brain cells involved in control of the body’s homeostasis.  The hypothesis to be examined is that mitogen activated signaling pathways play a major role in mediating effects of pro-inflammatory cytokines in the CNS.
• 06/07/00  "In-House" Grant application has been approved for funding!
  Grant application entitled "Role of Estrogen Signaling during Regeneration in the Nervous System" has been approved by the Research Committee of The Brody School of Medicine for funding.  The funding will be provided for one year and will help to generate preliminary data for obtaining external grant support.   We thank the Committee for recognition and support of our research.
• 04/01/00  Subcontract with Columbia University, New York!
  The subcontract with Columbia University has been established to collaborate with Dr. Debra J. Wolgemuth, Ph.D. on NASA project "Development and Function of the Mouse Vestibular System in the Absence of Gravity Perception".

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