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Michael R. Van Scott, Ph.D.

Professor

Physiology Department

vanscottmi@mail.ecu.edu

1981		B.S., Cornell University, Ithaca, NY
1984		Ph.D., West Virginia University, Morgantown, WV
1984		Post-Doc., University of North Carolina, Chapel Hill, NC

Address

   Dr. Michael R. Van Scott
   East Carolina University
   Brody School of Medicine
   Physiology Department
   600 Moye Blvd.
   6E-110 Brody Bldg.
   Greenville, NC  27858-4354

Research Interests

		Physiology Research Program summary
		Community of Science listing

Interactions between airway inflammatory, epithelial, neural, and smooth muscle
Pathophysiologic processes underlying airway dysfunction in obstructive lung disease
Definition of molecular targets with therapeutic relevance in asthma
Evaluation of novel therapeutic approaches to treating lung disease

Recent Publications

Van Scott, M.R., T.C. Chinet, A.D. Burnette, A.M. Paradiso.
Purinergic regulation of electrogenic ion transport across nonciliated bronchiolar epithelial cells.
Am. J. Physiol. 269:L30-L37, 1995.

Van Scott, M.R., C. Penland, C.A. Welch, E. Lazarowski.
ß-Adrenergic stimulation of Cl- and HCO3- secretion by rabbit Clara cells.
Am. J. Respir. Cell and Mol. Physiol. 13:344-351, 1995.

Ghosh, T.K., M.R. Van Scott, O.P. Mathew.
Epithelial modulation of afferent nerve endings: differential effects of amiloride on afferent subtypes.
J. Appl. Physiol.78(6):2235-2240, 1995.

VanScott, M.R., M.D. Smith, C.A. Welch, C. Bentzel, and W.J. Metzger.
Bioelectric response of human nasal epithelial cells to polycationic protein.
Am. J. Physiol. 271 (Lung Cell. Mol. Physiol. 15): L159-L165, 1996.

Ghosh, T.K., M.R. Van Scott, and O.P. Mathew.
Role of epithelial ion transport on the activation of water-responsive laryngeal afferents.
Respir. Physiol. 105:163-169, 1996.

M.D. Smith, C.M. Penland, M.R. Van Scott.
Differential effects of polycationic protein in Cl- secretory and Na+ absorptive airways.
Am. J. Physiol. 272:L762-771, 1997.

Chinet, T.C., S.E. Gabriel, C.M. Penland, M. Sato, M.J. Stutts, R.C. Boucher, and M.R. Van Scott.
CFTR-like chloride channels in nonciliated bronchiolar epithelial (Clara) cells.
Biochem. Biophys. Res. Commun. 230:470-475, 1997.

D.W. Hay, M.R. Van Scott, and R.M. Muccitelli.
Characterization of endothelin release from guinea-pig tracheal epithelium: influence of proinflammatory mediators including major basic protein.
Pulm. Pharm. Ther. 10(4):189-198, 1997.

Y. Shibata, L.A. Foster, M. Kurinmoto, H. Okamura, R.M. Nakamura, K. Kawajiri, J. P. Justice, M.R. Van Scott, Q.N. Myrvik, and W.J. Metzger.
Immunoregulatory roles of IL-10 in innate immunity: IL-10 inhibits macrophage production of IFN-gamma inducing factors but enhances NK cell production of IFN-gamma.
J. Immunol. 161(8):4283, 1998.

J Dortch-Carnes, M.R. Van Scott, and J.S. Fedan.
Changes in smooth muscle tone during osmotic challenge in guinea-pig trachea in relation to epithelial bioelectric events.
J. Pharmacol. Exp. Ther. 289(2):911-917, 1999.

M.R. Van Scott, J.P. Justice, J. Bradfield, A. Sigounas, E. Enright, and S. Sur.
IL-10 reduces Th2 cytokine production and eosinophilia but augments airway reactivity in allergic mice.
Am. J. Physiol.: Lung, Cell. Mol. Physiol. 278:L667-674, 2000.

Sur, S., J. Lam, B.K. Choudhury, P. Bouchard, J.S. Wild, N. Sur, R. Alam, A. Sigounas, D. Holbert, and M.R. Van Scott.
Mucosal IL-12 is more effective than systemic IL-12 in up-regulating IFN-gamma expression and inhibiting allergic lung eosinophilia.
Exp. Lung. Res. (In press).

Sur, S., P. Bouchard, D. Holbert, and M.R. Van Scott.
Mucosal IL-12 is more effective than systemic IL-12 in inhibiting airway reactivity to methacholine and respiratory failure in murine asthma.
Exp. Lung Res. (In press).

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