Research Professor

M.D. Shanghai First Medical College, 1955

Research Subject Areas

• The Micronuclei (MN) Production in Cytokinesis-Blocked Human Peripheral Blood Lymphocytes (PBL)
•   Radioprotective Effect of Panax Ginseng on Human PBL ex vivo
•   Radioprotective Effect of WR-1065 on Human PBL ex vivo

Grants

• NIH/NCCAM - Lee TK (PI), Johnke RM (CI), O'Brien KF (Collaborator), Allison RR (Consultant), R21-AT002639-01A1, Title: Radioprotective Potential of Ginseng. Award Amount: $320,626 (09/01/2005 - 08/31/2007)

Selected Publications

1. Lee TK, Wang W, O'Brien KF, Johnke RM, Wang T, Allison RR, Diaz AL. Effect of North American ginseng on 137Cs-induced micronuclei in human lymphocytes: a comparison with WR-1065. Phytother Res. 2008 Dec;22(12):1614-22.
2. Lee TK, Allison RR, O'Brien KF, Johnke RM, Arastu H,  Radiotherapeutic morbidity may be predicted by micronuclei in lymphocytes of 75 cancer patients. American Radium Society Proceedings, P13, 2006.
3. Lee TK, Johnke RM, Allison RR, O'Brien KF, Dobbs LJ, Radioprotective potential of ginseng. Mutagenesis 2005, 20:237-243.
4. Lee TK, Allison RR, O'Brien KF, Johnke RM, Wiley AL, Jr. Karlsson UL, Arastu H. Radiotherapy-induced micronuclei in lymphocytes of 107 cancer patients is associated with radiation morbidity. American Association for Cancer Research, 96th Annual Meeting, April 17, 2005, Anaheim, CA.
5. Lee TK, Allison RR, O'Brien KF, Khazanie PG, Johnke RM, Brown R, Bloch RM, Tate ML, Dobbs LJ, Kragel PJ. Ginseng reduces the micronuclei yield in lymphocytes after irradiation. Mutation Research 2004, 557:75-84.
6. Lee TK, Allison RR, O'Brien KF, Johnke RM, Kovacs  CJ, Karlsson UL, Micronuclei may predict radiotherapy-induced morbidity in prostate cancer patients. American Association for Cancer Research, Proceedings of the  95th Annual Meeting, Vol. 45 (Abstract #3128), 2004.
7. Lee TK, Allison RR, O'Brien KF, Johnke RM, Kovacs  CJ, Tate ML, Karlsson UL, Wiley AL, Jr. Micronuclei in lymphocytes may predict radiation morbidity in patients with solid tumors. Int J Radiat Oncol Biol Phy 2004, 60 :S368.
8. Lee TK, Allison RR, O'Brien KF, Kovacs  CJ, Kalika S. Radioprotection of WR-1065 on human lymphocytes. The Cancer J 2004, 10 (Sup. 1):44.
9. Lee TK, Allison RR, O'Brien KF, Johnke RM, Kovacs  CJ, Tate ML, Karlsson UL, Wiley AL, Jr. Intrinsic radiosensitivity determined by micronuclei production in lymphocytes; correlation with radiation morbidity in patients with malignancies of lung, and head and neck. Lung Cancer 2004, 46 (Sup. 1):S46-S47.
10. Lee TK, Allison RR, O'Brien KF, Johnke RM, Christie KI, Naves JL, Kovacs CJ, Arastu H, Karlsson UL. Lymphocyte radiosensitivity correlated with pelvic radiotherapy morbidity.Int J Radiation Oncol Biol Phys 2003; 57: 222-229.
11. Fenech M., Bonassi S, Turner J, Ceppi M, Chang WP, Holland N, Lee TK, et al. Intra - and inter-laboratory variation in the scoring of micronuclei: and nucleo- plasmic bridges in binucleated human lymphocytes.  Results of an international slide-scoring exercise by the HUMN project.  Mutation Research 2003; 534:45-64.
12. Lee TK, Allison, RR, O'Brien KF, Naves JL, Karlsson UL, Wiley AL.Jr. Persistence of micronuclei in lymphocytes of cancer patients after radiotherapy.  Radiation Research 2002; 157:678-684
13. Bonassi S, Fenech M, Lando C, Lin Y-P, Ceppi M, Chang WP, Holland N, Lee TK, et al. Human micronucleus project: International database comparison for results with the cytokinesis-block MN assay in human lymphocytes: 1. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of MN.  Environmental and Molecular Mutagenesis 2001; 37:31-45.
14. Lee TK, O'Brien KF, Naves JL, Christie KI, Wiley AL, Jr; Karlsson UL.  Micronuclei in lymphocytes of prostate cancer patients undergoing radiation therapy. Mutation Research 2000; 469:63-70.
15. Lee TK, O'Brien KF, Eaves GS, Christie KI, Varga L. Effect of blood storage on radiation-induced micronuclei in human lymphocytes. Mutation Research 1999; 444:201-206
16. Lee TK, O'Brien KF, Karlsson UL, Christie K, Wiley AL Jr. Effect of ex vivo hyperthermia on radiation-induced micronuclei in Iymphocytes of cancer patients before and during radiotherapy. Mutation Research 1998; 417:1-8.

Selected Presentations

Ed Warren Life Sciences 002
The Brody School of Medicine
Greenville, NC 27858-4354
Telephone: (252) 744-3768
Fax: (252) 744-3775

email: leet@ecu.edu

Department of Radiation Oncology
The Brody School of Medicine at East Carolina University
600 Moye Blvd.
Greenville, NC 27834
Phone (252) 744-2900 / Fax (252) 744-2812

T.K. Lee, M.D.

General Information

Patients

Professionals

Future Students

1. Lee TK, O'Brien KF, Wang W, Johnke RM, Allison RR. "Dietary supplement of North American ginseng reduces micronucleous formation formation in human lymphocytes after irradiation", presented at American Association for Cancer Research 2008 Annual Meeting, April 14, 2008, San Diego, CA.
2. Lee TK, Wang W, O'Brien KF, Johnke RM, Allison RR, Diaz AL, "Effect of American ginseng on radiation-induced micronuclei in human lymphocytes; A comparison with WR-1065", presented at American Radium Society 90th Annual Meeting, May 4, 2008, Dana Point, CA.
3. Oral Presentation: Lee TK, Allison RR, O'Brien KF, Johnke RM, Arastu H, Radiotherapeutic morbidity may be predicted by micronuclei in lymphocytes of 75 cancer patients, American Radium Society 88th Annual Meeting, May 8, 2006, Maui, Hawaii.
4. "Lymphocyte Radiosensitivity is Correlated with Pelvic Radiotherapy Morbidity", The 44th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), New Orleans, LA, October 9, 2002.
5. "Ginseng Reduced the MN yield in Lymohicytes After Irradiation", The 49th Annual Meeting of the Radiation Research Society, April 21, 2002, Reno, Nevada.
6. "Biodosimetric assessment of MN in Lymphocytes of Patients With Pelvic RT", The 43rd  Annual Meeting of ASTRO, November 5, 2001, San Francisco, CA.