Barbara J. Muller-Borer, PhD

Barbara J. Muller-Borer

Associate Professor
The Brody School of Medicine

East Carolina Heart Institute at ECU
115 Heart Drive, Room #2247, Greenville, NC 27834

252-744-2546 (phone)


  • Undergraduate: Tufts University School of Engineering
  • Graduate Studies: University of North Carolina at Chapel Hill
  • Fellowship: University of North Carolina School of Medicine

Research Interests

  • Cardiac Electrophysiology
  • Cell-to-Cell Communication
  • Stem Cell-Based Therapies
  • Computational Biology


Collins MC, Moore JL, Burrows BJ, Kypson AP, Muller-Borer BJ. ""Early cell loss associated with mesenchymal stem cell cardiomyoplasty"", The Open Tissue Engineering and Regenerative Medicine Journal, 2012, April; 5: 17-24

Muller-Borer BJ, Esch GL, Aldina R, Woon, Fox R, Bursac N, Hiller S, Maeda N, Shepherd N, Jin JP, Hutson M, Anderson PAW, Kirby M, Malouf NN. "Calcium Dependent CAMTA1 in Adult Stem Cell Commitment to a Myocardial Lineage", PLoS One. 2012;7(6):e38454. Epub 2012 Jun 8.

Joshi C, Martin DN, Shaver P, Madamanchi C, Muller-Borer BJ, Tulis DA. "Control of Vascular Smooth Muscle Cell Growth by Connexin 43", Front Physiol. 2012;3:220. Epub 2012 Jun 21.

Collins MC, Gunst PR, Cascio WE, Kypson AP, Muller-Borer BJ. Labeling and Imaging Mesenchymal Stem Cells with Quantum Dots. Nanoparticles in Biology and Medicine. Methods Mol Biol. 2012;906:199-210, Humana Press, USA.

Burrows, B. J., Collins, M. C. , Muller-Borer, B. J. , & Kypson, A. P. (2008). 'Cellular Cardiomyoplasty: Results of Injected Human Mesenchymal Stem Cell Survival Rates in a Beating Rat Heart Model'. Journal of Surgical Research, 144 (2), 274-5.

Carter, J. J., Manwaring, M. L. , Salleng, K. J. , Muller-Borer, B. J. , Collins, M. C. , & Stoner, M.C., (2008). Paralysis and Cell Death from Thoracic Aortic Stenting Ameliorated by Peroxynitrite Decomposition Catalyst. Journal of the American College of Surgeons, 207 (3 sup), 22. | PDF

Muller-Borer, B. J., Collins, M. C. , Gunst, P. R. , Cascio, W. E. , & Kypson, A. P. (2007). Quantum Dot Labeling of Mesenchymal Stem Cells. Journal of Nanobiotechnology, 5-9. | PDF

Anderson, P. A.W., Muller-Borer, B. J. , Esch, G. K. , Coleman, W. B. , Grisham, J. W. , Malouf, N.N., (2007). Calcium Signals Induce Liver Stem Cells to Acquire a Cardiac Phenotype. Cell Cycle, 6 (13), 1565-1569. | PDF

Hudson, W., Collins, M. C. , deFrietas, D., Sun, Y. S. , Muller-Borer, B. J. , Kypson, A.P., (2007). Beating and arrested intramyocardial injections are associated with significant mechanical loss: implications for cardiac cell transplantation. Journal of Surgical Research, 142, 263-267. | PDF

Muller-Borer, B. J., Cascio, W. E. , Esch, G. L. , Kim, H. S. , Coleman, W. B. , Grisham, J.W. Anderson, P.A.W. Malouf, N.N, (2007). Mechanisms controlling the acquisition of a cardiac phenotype by liver stem cells. Proceedings of the National Academy of Science USA, 6 (104), 3877-3882. | PDF

Muller-Borer, B. J., Gunst, P. R. , Collins, M. C. , Cascio, W. E. , & Kypson, A. P. (2006). 'Long-Term Labeling of Mesenchymal Stem Cells Using Quantum Dot Bioconjugates'. Circulation, 114 (18), II-662.

Muller-Borer, B. J., Cascio, W. E. , Esch, G. L. , Grisham, J. W. , Anderson, P. A. , Malouf, N.N., (2006). Acquired cell-to-cell coupling and cardiac-like calcium oscillations in adult stem cells in a cardiomyocyte microenvironment. Conference Proceedings IEEE Engineering in Medicine and Biology, 1, 576-579. | PDF

Cascio, W. E., Yang, H., Muller-Borer, B. J. , & Johnson, T. A. (2005). Ischemia-induced arrhythmia: the role of connexins, gap junctions, and attendant changes in impulse propagation. Journal of Electrocardiology, 38 (4), 55-59. | PDF

Muller-Borer, B. (2004). Adult Derived Liver Stem Cells Acquire a Cardiomyocyte Structural and Functional Phenotype ex Vivo. American Journal of Pathology, 165, 135-145. | PDF

Henriquez, A. P., Vogel, R., Muller-Borer, B. J. , Henriquez, C. S. , Weingart, R., Cascio, W.E., (2001). Influence of dynamic gap junction resistance on impulse propagation in ventricular myocardium: a computer simulation study. Biophysical Journal, 81 (4), 2112-2121. | PDF

Cascio, W. E., Yang, H., Johnson, T. A. , Muller-Borer, B. J. , & Lemasters, J. J. (2001). Electrical properties and conduction in reperfused papillary muscle. Circ Res, 89 (9), 807-814. | PDF

Muller-Borer, B. J., Yang, H., Marzouk, S. A. , Lemasters, J. J. , & Cascio, W. E. (1998). pHi and pHo at different depths in perfused myocardium measured by confocal fluorescence microscopy. Am J Physiol Heart Circ Physiol, 275, H1937-H1947. | PDF

Christopher, H. J., Lemasters, J. J. , Muller-Borer, B. J. , Johnson, T. A. , & Cascio, W. E. (1998). A superfusion system to study border zones in confluent cultures of neonatal rat heart cells. Am J Physiol Cell Physiol, 274, H2001-H2008. | PDF

Muller-Borer, B. J., Johnson, T. A. , Gettes, L. S. , & Cascio, W. E. (1995). Failure of impulse propagation in a mathematically simulated ischemic border zone: influence of direction of propagation and cell-to-cell electrical coupling. J Cardiovascular Electrophysiol, 6 (12), 1101-1112. | PDF

Muller-Borer, B. J., Erdman, D. J. , & Buchanan, J. W. (1994). Electrical coupling and impulse propagation in anatomically modeled ventricular tissue. IEEE Transactions in Biomedical Engineering, 41 (5), 445-454. | PDF