Teaching Professor of Pathophysiology
Ledyard E. Ross Hall
Regulation of mitochondrial superoxide production, dental education, basic sciences
American Dental Education Association
American Physiological Society
American Heart Association / American Stroke Association
International Association of Medical Science Educators
National Academy of Scholars
Iowa Physiological Society (honorary lifetime member)
Born in Manhattan, NY Dr. McCabe served 10 years in the Navy before receiving his BS in Biology from Kansas State University and PhD in Physiology from the University of Kansas Medical Center, where he also did his post-doctoral studies. Dr. McCabe’s dissertation was awarded honors status and he received undergraduate honors and scholarships and a graduate teaching assistantship.
Dr. McCabe’s previous research focused on potassium transport, regulation and cardiovascular protection. The former work overturned the then leading theory on the mechanisms of epithelial potassium transport. The latter work was cited by the National Academy of Science in its rationale for the present US Recommended Dietary Intake for potassium as well as the National Council on Potassium in Clinical Practice for present Guidelines for Potassium Replacement in Clinical Practice. Dr. McCabe has taught clinical biosciences and biology to dental, medical, nursing, pharmacy, podiatry, physician assistant, physical therapy, biology and other students for over thirty years. Dr. McCabe has won three teaching awards, 8 research grants and one research award.
1. McCabe RD, Cooke HJ, Sullivan LP. Potassium transport by rabbit descending colon. Am. J. Physiol. 242: C81-C86, 1982.
2. McCabe RD, Smith PL, Sullivan LP. Ion transport by rabbit descending colon: Mechanisms of transepithelial potassium transport. Am. J. Physiol. 246: G594-G602, 1984.
3. McCabe RD, Smith PL. Effects of histamine and histamine receptor antagonists on ion transport in rabbit descending colon. Am. J. Physiol. 247: G411-G418, 1984.
4. Smith PL, McCabe RD. Mechanism and Regulation of transcellular potassium transport by the colon. Am. J. Physiol. 247: G445-G456, 1984.
5. Smith PL, McCabe RD. A23187-induced changes in colonic potassium and chloride transport are mediated by separate mechanisms. Am. J. Physiol. 247: G695-G702, 1984.
6. McCabe RD, Smith PL. Colonic potassium and chloride secretion: Role of cAMP and Calcium. Am. J. Physiol. 248: G103-G109, 1985.
7. Smith PL, Sullivan SK, McCabe. RD Concentration-dependent effects of disulfonic stilbenes on colonic chloride transport. Am. J. Physiol. 250: G44-G49, 1986.
8. Smith PL, McCabe RD. Potassium secretion by rabbit descending colon: Effects of adrenergic stimuli. Am. J. Physiol. 250: G432-G439, 1986.
9. McCabe RD, Dharmsathaphorm K. Mechanism of VIP-stimulated chloride secretion by intestinal epithelial cells. Annals. N. Y. Acad. Sci. 527:326-345, 1988.
10. McCabe RD, Young DB. Evidence of a K+, H+-ATPase in vascular smooth muscle
cells. Am. J. Physiol. 262: H1955-H1958, 1992.
11. McCabe RD, Smith MJ, Dwyer TM. Aldosterone secretion and the mechanisms of potassium adaptation in rats. Steroids 58:305-313, 1993.
12. McCabe RD, Young DB. Potassium inhibits cultured vascular smooth muscle cell proliferation. Am. J. Hypertens. 7:346-350, 1994.
13. McCabe RD, Smith MJ, Dwyer TM. Faecal dry weight and potassium are related to faecal sodium and plasma aldosterone in rats chronically fed varying amounts of sodium or potassium chlorides. Br. J. Nutr. 72:325-337, 1994.
14. McCabe RD, Bacharach MS, Srivastava K, Young DB. Potassium inhibits free radical formation. Hypertension. 24:77-82, 1994.
15. Young DB, Lin H, McCabe RD. Potassium's cardiovascular protective mechanisms. Am. J. Physiol. 268: R825-R837, 1995.