The goal of this study is to determine if there are differences in the composition of mucosal cell types in the GI tract of diabetic and non-diabetic patients.
The goal of this study experiment involves studies of diabetic and non-diabetic patients before they undergo gastric bypass surgery. Ten non-diabetic and 20 diabetic patients will be studied. Endoscopies to biopsy the described areas of the GI tract will be performed by Dr. John Pender, Department of Surgery, Brody School of Medicine. The cell composition of the GI biopsies will be analyzed by Dr. Allan Smith, Department of Pathology: The Brody School of Medicine at East Carolina University. Fixing, staining, and immunohistochemistry will be done by established techniques in the Department of Pathology.
1) Male and Female
2) 18-60 years of age
3) BMI of 35 to 65
4) Willing to comply with study requirements
5) Capable of understanding the requirements and consequences of the study
6) Has a negative pregnancy test (performed on women of childbearing potential) non-childbearing potential is defined as being 12 months post-menopausal or having had a sterilization procedure)
1) Repeat gastric bypass procedure
2) Patients taking TZD’s (thiazolidinediones).
All patients will be reimbursed $100.00 for their time and participation with the endoscopic biopsies. All patients will receive $25.00 per blood draw to assist with travel expenses to the study center (samples drawn at pre- and post- surgery visits for a total of $50.00).
Hunter Gay, Program Coordinator