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Division of Health SciencesThe Harriet and John Wooten Laboratory

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In The News

Research Efforts

The Wooten Laboratory is a co-sponsor of the Annual Symposia of East Carolina Chapter of Society for Neuroscience (ECCSN) from 2008 to 2016. The annual meetings are held in October or November each year in Greenville, North Carolina. The Wooten Laboratory has supported the Wooten Lectures given by distinguished clinicians or scientists investigating Alzheimer's disease and/or other neurodegenerative diseases ( view ECCSN website).The Wooten Laboratory has also funded and presented awards for Best Student Presentation at the symposia.

In October of 2008, The Wooten Laboratory sponsored Dr. Michael Irizarry, MD, MPH from GlaxoSmithKline, and Epidemiology Division for the talk titled "Biomarkers and Imaging Markers in Alzheimer's Disease" at 10th Annual Neuroscience Symposium.

In October of 2009, The Wooten Laboratory sponsored Dr. Donald Price, MD, Director of Johns Hopkins University Alzheimer's Disease Center and Dr. Dwight German of University Texas Southwestern m Medical Center to deliver the Wooten Lectures on Alzheimer's disease research at 11th Annual Neuroscience Symposium.

In February of 2010, the funding of six Wooten projects was announced to investigate the molecular and cellular mechanisms of Alzheimer's disease and other neurological disorders.

In September of 2010, Dr. Alex Murashov received a grant from National Institute for Environmental Health Sciences to study microRNA pathway in mechanisms of nanoparticles neurotoxicity.

In October of 2010, Dr. Qun Lu published a paper in Journal of Alzheimer's Disease entitled "Alzheimer's disease-linked presenilin mutation (PS1M146L) induces filamin expression and gamma-secretase independent redistribution".

In November of 2010, the Wooten Laboratory co-sponsored the 12th annual East Carolina Neuroscience Symposium and the Wooten Lecture by Dr. Sandra Kelly of University of South Carolina.

In February of 2011, the Wooten Laboratory received a $100,000 donation to accelerate translational research and promote Wooten Laboratory research efforts.

In February of 2011, the funding of six Wooten projects was announced to investigate the molecular and cellular mechanisms of Alzheimer's disease-like pathogenesis in transgenic mice.

In May of 2011, Dr. Qun Lu received funding from PharmaTrophix for Alzheimer's disease drug applications in peripheral neurodegenerations.

In July and September of 2011, Dr. Mark Mannie received two grants from National Institute of Neurological Disorders and Stroke to study therapeutic vaccines (TTV) in murine experimental autoimmune encephalomyelitis (EAE).

In September of 2011, Dr. Qun Lu, with the assistance and support of ECU Department of marketing professor Dr. Margy Conchar, has produced the Wooten Visibility. It was distributed on Sept. 17, 2011 at the Raleigh Alzheimer's Walk, Oct. 15, 2011 at the Washington Walk, and Nov. 12, 2011 at the Greenville Walk.

In November of 2011, the Wooten Laboratory sponsored ECU Wooten Laboratory member Dr. Mark Mannie as the Wooten Lecturer in the 13th annual Neuroscience Symposium.

In September of 2011, the Wooten Laboratory received a $100,000 donation to accelerate translational research and promote Wooten Laboratory research efforts.

In May of 2012, Dr. Qun Lu received a three-year grant from National Cancer Institute to study Rho GTPase as neuroprotection target in chemotherapy-induced neurodegeneration.

In November of 2012, the Wooten Laboratory sponsored Dr. Oscar Lopez, Director of University of Pittsburg Alzheimer's Disease Research Center, as the Wooten Lecturer in the 14th annual Neuroscience Symposium.

In November of 2012, the Wooten Laboratory sponsored Dr. Weiming Xia from VA Hospital in Boston, to deliver a talk in the14th annual Neuroscience Symposium and The Wooten Roundtable Discussion.

In January of 2013, Dr. Qun Lu published a paper in PNAS entitled "Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility". A press release on its relevance to Alzheimer’s disease can be found at http://www.ecu.edu/news/newsstory.cfm?id=2631.

In February of 2013, the Wooten Laboratory presented to Eli Lily representatives for partnership discussion on neurodegenerative diseases research.

In May of 2013, Drs. Sonja Bareiss and Kori Brewer published a paper in Neuroscience Letter, titled "Excitotoxic spinal cord injury induced dysesthesias are associated with enhanced intrinsic growth of sensory neurons".

In June of 2013, the Wooten Laboratory received a research grant of $50,000 from Alzheimer's North Carolina, Inc. A press release on the grant title "A Multidisciplinary Approach to Fight Senior Dementia I: study physical exercise and cortical training on Alzheimer-like pathogenesis in mice." can be found at http://www.ecu.edu/news/newsstory.cfm?id=2798.

In July of 2013, Dr. Qun Lu presented at Alzheimer Association International Conference in Boston, with the poster title "Small molecules targeting Rho GTPase signaling altered in Alzheimer's disease".

In April of 2014, the Wooten Laboratory received a research grant of $50,000 from Alzheimer's North Carolina, Inc with the title "A Multidisciplinary Approach to Fight Senior Dementia II: study of accelerated Alzheimer's mouse model and developmental toxicity".

In October of 2014, Dr. Mark Mannie published a paper entitled "The extracellular domain of myelin oligodendrocyte glycoprotein elicits atypical experimental autoimmune encephalomyelitis in rat and Macaque species" in PLoS One.

In June of 2015, Dr. Kori Brewer and Dr. Sonja Bareiss published a paper entitled "PI3K mediated activation of GSK-3β reduces at-level primary afferent growth responses associated with excitotoxic spinal cord injury dysesthesias" in Molecular Pain.

On Jan 15 of 2015, ECU released the news that Drs. Sonja Bareiss and Kori Brewer were awarded a two-year, $300,000 grant by the Craig H. Neilsen Foundation to study the development and possible treatments of the debilitating pain that commonly occurs after a spinal cord injury. The press story described how they have collaborated since 2010, when they received seed funding from the Harriet and John Wooten Lab for Alzheimer's and Neurodegenerative Diseases Research, which aims to jump-start Brody faculty on multidisciplinary research projects about molecular and cellular mechanisms involved in neurodegenerative diseases. Read the full story.

In January of 2016, Dr. Sonja Bareiss and Dr. Qun Lu published a paper entitled "Early alterations in blood and brain RANTES and MCP-1 expression and the effect of exercise frequency in the 3xTg-AD mouse model of Alzheimer's disease" in Neuroscience Letter.

In May of 2016, Dr. Mark Mannie received a five-year grant from National Institute of Allergy and Infectious Diseases on "Interferon-beta as an adjuvant for tolerogenic vaccination". The purpose of this research is to understand mechanisms by which IFN-β drives tolerogenic FOXP3+ T cell responses in mouse models of the neurodegenerative disease Experimental Autoimmune Encephalomyelitis (EAE), which is a prototypic model for the human demyelinating disease Multiple Sclerosis.

In October of 2016, Dr. Qun Lu Q published a paper entitled "Genetic alterations of δ-catenin/NPRAP/Neurojungin (CTNND2): functional implications in complex human diseases" in Human Genetics.

On October 15 of 2016, Dr. Mark Mannie published a paper entitled "IFN-β Facilitates Neuroantigen-Dependent Induction of CD25+ FOXP3+ Regulatory T Cells That Suppress Experimental Autoimmune Encephalomyelitis" in Journal of Immunology.

In October of 2016, Dr. Mark Mannie published a paper entitled "Depletion of CD4+ CD25+ regulatory T cells confers susceptibility to experimental autoimmune encephalomyelitis (EAE) in GM-CSF-deficient Csf2-/- mice" in Journal of Leukocyte Biology.

In March of 2017, Dr. Stefan Clemens published in paper entitled "Connectome and molecular pharmacological differences in the dopaminergic system in restless legs syndrome (RLS): plastic changes and neuroadaptations that may contribute to augmentation" in Sleep Medicine.

In May of 2017, Dr. Stefan Clemens and Dr. Kori Brewer published a paper entitled "Morphine responsiveness to thermal pain stimuli is aging-associated and mediated by dopamine D1 and D3 receptor interactions" in Neuroscience.

In July of 2017, Dr. Kori Brewer and Dr. Stefan Clemens, received a two-year grant from the Craig H. Neilsen Foundation to study neuropathic pain.

On August 17 of 2017, Dr. Jamie DeWitt and Annaliese vonderEmbse published a paper in Journal of Developmental Origins of Health and Disease entitled "Developmental toxicant exposure in a mouse model of Alzheimer's disease induces differential sex-associated microglial activation and increased susceptibility to amyloid accumulation".

In October of 2017, Dr. Byron Aguilar and Dr. Qun Lu were awarded a two-year grant from Alzheimer's Association entitled "Elucidating the therapeutic potential of intersectin in Alzheimer's disease" to study small molecules that inhibit Alzheimer-like pathogenic process in mouse model.

In November of 2017, Dr. Qun Lu's group report the study entitled "Re-evaluating Rho GTPase signaling as a potential therapeutic target for Alzheimer's disease" at Annual Society for Neuroscience Meeting in Washington DC.


Community Awareness and Visibility

In May of 2010, Dr. Qun Lu and Dr. Irene Hamrick visited Cypress Glen Memory Center. They toured the facility and discussed the care of dementia patients in eastern North Carolina with Laura Jett, Director of Memory Care unit.

In May and June of 2010, Dr. Qun Lu participated in round table discussion about legal issues regarding the care of dementia patients and communication with their families.

In May and August of 2010, Dr. Irene Hamrick and Dr. Qun Lu continued to rally support for the Alzheimer’s Walk (sponsored by www.gotricounty.com of Alzheimer’s Foundation) to be held in Washington, North Carolina in October of 2010.

In October of 2010, Dr. Sonja Bareiss led the Wooten Laboratory and participated in the Washington Alzheimer Walk. The Walk (sponsored by AlzNC) donated $1,000 to the Wooten Laboratory for research in Alzheimer’s disease.

In October of 2011, Dr. Daniel Lee, Dr. Qun Lu, and Dr. Sonja Bareiss participated in the education exhibits at Washington Alzheimer Walk. Dr. Jean Weng, a visiting clinical pharmacologist in Dr. Qun Lu’s research group, also participated in the Walk. The Walk (sponsored by AlzNC) donated $5,000 to the Wooten Laboratory for research in Alzheimer’s disease.

In October of 2012, Dr. Daniel Lee, Dr. Qun Lu, and Dr. Sonja Bareiss participated in the education exhibits at Washington Alzheimer Walk. Dr. Qun Lu, as well as Dr. Yan-hua Chen of ECU walked with hundreds of supporters for ~2 miles. The Walk has pledged for further support for research at the Wooten Laboratory.

In November of 2012, Dr. Daniel Lee, Dr. Qun Lu, and Dr. Robert Lust participated in the education exhibits at Greenville Alzheimer Walk. They also walked with thousands of supporters for ~1 miles.

In September of 2013, Dr. Jamie DeWitt gave a presentation to the Alzheimer’s Professional Partnership meeting in Greenville. Its title was: “Alzheimer’s disease and neurodegenerative disorders research at East Carolina University”.

In November of 2013, Dr. Tae Lee, Dr. Qun Lu and Dr. Robert Lust participated in the education exhibits at Greenville Alzheimer Walk. They also walked with thousands of supporters for ~1 miles.

In November of 2013, Dr. Jamie DeWitt gave a presentation to a senior group at Vidant. It was titled “The nuts and bolts of Alzheimer’s disease research at ECU”.

In September of 2014, Drs. Sonja Bareiss, Yan-Hua Chen, Jamie DeWitt, and Tuan Tran along with Dr. Qun Lu, participated in the education exhibits at Washington Alzheimer Walk. Dr. Bob Lust also joined in the Walk. The Walk (sponsored by AlzNC) raised $30,000 in this 10th annual Alzheimer’s Walk in Washington.

In March of 2017, Alzheimer’s Walk in Washington of North Carolina donated $5,000 to the Wooten Laboratory for research in Alzheimer’s disease.

In March of 2017, Dr. Lamont Wooten visited the Wooten Laboratory and pledged more funding to support the research using the Alzheimer’s mouse model.

On October 7th of 2017, Dr. Tuan Tran and the ECU Neuroscience Undergraduate team participated in Alzheimer’s Walk in Washington, North Carolina. Dr. Tran represented the Wooten Laboratory as the scientific expert for the education and fund raising event.